This guide was created in response to the impact on human rights protection during the Covid-19 pandemic. The first part of the publication analyses the rights in the European Convention on Human Rights that have been most affected by the Covid-19 pandemic and by government responses to contain it. The authors have based their findings on the Convention provisions and the judgments and decisions most relevant to the legal issues raised by the pandemic and applied the existing case law of the European Court of Human Rights to the novel set of facts which may come before courts. The guide tackles key issues such as derogation from the Convention, access to courts and the right to medical treatment and is a useful tool in interpreting and applying Convention Rights in the context of the Covid-19 crisis. Part two of the guide contains summaries of the Court’s case-law identified as most relevant to the Convention rights discussed in Part one.